Anthrax

Category: generalpediatrics-Infectious Disease

Findings: painless ulcer that becomes black eschar, painless induration, pruritic blisters, farm animals, flu-like illness

Question: What fits these findings?


Ascaris Lumbricoides

Category: generalpediatrics-Infectious Disease

Findings: intestinal obstruction, bronchitis, shifting infiltrates on chest x-ray, eosinophilia

Notes: Treat with albendazole or pyrantel pamoate


Aspergillus

Category: generalpediatrics-Infectious Disease

Findings: lung infiltrates, eosinophilia, cough

Notes: Treat with itraconazole and steroids. If invasive, treat with amphotericin.

Question: What fits these findings?


Bartonella Henselae

Category: generalpediatrics-Infectious Disease

Findings: tender lymphadenopathy, history of cat or dog exposure, self-limiting

Notes: Generally self-limiting but treat immunocompromised patients or ones who have severe symptoms with antibiotics such as macrolides, doxycycline, bactrim, or cephalosporins.

Question: What fits these findings?


Ceftriaxone

Category: generalpediatrics-Infectious Disease

Findings: three day old full term infant with purulent conjunctivitis, no hyperbilirubinemia

Notes: Treat suspected neonatal gonococcal conjunctivitis with single dose of IM or IV ceftriaxone and admit to hospital to observe for response to therapy. If infant is preterm, has hyperbilirubinemia, is getting calcium-infused fluids, use IV or IM cefotaxime or ceftazidime to prevent precipitation and displacement of bilirubin from albumin. Irrigate eye frequently to clear discharge.

Question: Which antibiotic do you use to treat the following?


Chlamydia Trachomatis

Category: generalpediatrics-Infectious Disease

Findings: staccato cough in infants, unilateral tender inguinal lymphadenopathy, intracytoplasmic inclusions

Notes: Treat with doxycycline or a macrolide

Question: What fits these findings?


Citrobacter Freundii

Category: generalpediatrics-Infectious Disease

Findings: brain abscess, urinary tract infections, sepsis, meningitis

Notes: Consider Staph aureus if there is a brain abscess and history of cyanotic heart disease

Question: What fits these findings?


Cryptosporidium

Category: generalpediatrics-Infectious Disease

Findings: diarrhea, contaminated drinking water, acid-fast organism, treated with nitazoxanide

Notes: Diagnose with stool antigen or PCR. Self-limiting disease.

Question: What fits these findings?


Entamoeba Histolytica

Category: generalpediatrics-Infectious Disease

Findings: tenesmus, abdominal pain, liver abscesses, travel to Southwest US

Notes: Diagnose with serologic testing and treat with metronidazole or iodoquinol


Epstein-Barr Virus (mononucleosis)

Category: generalpediatrics-Infectious Disease

Findings: atypical lymphocytes, exudative pharyngitis, long-lasting fever, hepatomegaly, diagnosed with IgM titers


Hookworm

Category: generalpediatrics-Infectious Disease

Findings: anemia, fatigue, coughing and wheezing, abdominal pain, malnutrition

Notes: Hookworm enters bare feet through soil, then goes to lungs and gastrointestinal system. It consumes nutrients and causes iron deficiency anemia. Treat with albendazole and potentially iron supplementation.

Question: What fits these findings?


Lymphadenitis

Category: generalpediatrics-Infectious Disease

Findings: warm tender enlarged erythematous lymph nodes

Notes: Commonly caused by both bacteria and viruses. Most common bacterial causes are group A streptococcus and S, aureus. Consider anaerobic bacteria if child had history of poor oral hygiene and tularemia if child had contact with sick pets such as rabbits. Viruses such as EBV and CMV may cause subacute or bilateral presentations. Cat scratch disease, toxoplasmosis, TB, and non-tuberculous mycobacteria may also be considered. Noninfectious causes include neoplasms, Kawasaki, MIS-C, and PFAPA among others. Well-appearing children with minimal tenderness may be monitored while labs including cultures, CBC, and inflammatory markers should be obtained and empiric antibiotics started to treat S. aureus and GAS if there are signs of significant clinical illness.

Question: What fits these findings?


Oral Vancomycin

Category: generalpediatrics-Infectious Disease

Findings: severe Clostridium difficile infection in pediatric patient

Notes: Metronidazole may be recommended in fulminant disease.

Question: Which antibiotic do you use in the following scenario?


Peritonsillar Abscess

Category: generalpediatrics-Infectious Disease

Findings: unilateral tonsillar swelling, difficulty opening mouth and speaking, drooling, painful swallowing, deviated uvula

Notes: Usually caused by group A strep. Treat with IV Unasyn and then Augmentin.

Question: What fits these findings?


Pertussis

Category: generalpediatrics-Infectious Disease

Findings: symptoms of mild URI, cough lasting several weeks in infants or adolescents, paroxysms of coughing, no or little fever, normal CBC, apnea in infant

Notes: Treat with azithromycin

Question: What fits these findings?


Retropharyngeal Abscess

Category: generalpediatrics-Infectious Disease

Findings: hyperextension of neck, fever, difficulty swallowing, lymphadenopathy

Question: What fits these findings?


Rocky Mountain Spotted Fever

Category: generalpediatrics-Infectious Disease

Findings: hyponatremia, thrombocytopenia, headache, lethargy, arthralgias, petechiae, rash starting at extremities and moving centripetally

Notes: Treat with doxycycline immediately if suspected. Usually found in mid-Atlantic states ranging from Virginia to New York (name is misnomer).

Question: What fits these findings?


Scarlett Fever

Category: generalpediatrics-Infectious Disease

Findings: strawberry or white tongue, sandpaper rash in creases

Question: What fits these findings?


Shigella

Category: generalpediatrics-Infectious Disease

Findings: high fever, tenesmus, bloody diarrhea, vomiting, seizures, rectal prolapse, elevated WBC and bandemia

Notes: Diagnose with stool culture. Treat severe cases with ceftriaxone or macrolide.

Question: What fits these findings?


Topical Ivermectin

Category: generalpediatrics-Infectious Disease

Findings: head lice resistant to two applications of permethrin

Notes: Also continue to comb out nits.

Question: What is the second line treatment for the following?


Toxocara Canis

Category: generalpediatrics-Infectious Disease

Findings: multiple systems affected, wheezing, abdominal pain, hepatosplenomegaly, leukocytosis, eosinophilia

Notes: Causes visceral larva migrans as round worms may migrate to intestines and lungs. Obtain serial chest x-rays.


Toxoplasma Gondii

Category: generalpediatrics-Infectious Disease

Findings: diffuse intracerebral ring-enhancing lesions, bilateral chorioretinitis, hydrocephalus, blueberry muffin rash

Notes: Obtain IgM titers. Treat with sulfadiazine or pyrimethamine. Is different from CMV as lesions in Toxoplasma are diffuse instead of periventricular as in CMV.

Question: What fits these findings?


Tularemia

Category: generalpediatrics-Infectious Disease

Findings: fever, lymphadenopathy, ulcers, hepatosplenomegaly, exposure to rabbits or deer

Notes: Treat with streptomycin, gentamicin, doxycycline, or ciprofloxacin.

Question: What fits these findings?